How BOTOX and Dermal Fillers Work Both BOTOX and dermal fillers target wrinkles, but the cause of those wrinkles determines which treatment is appropriate. BOTOX works by temporarily relaxing the muscles that cause dynamic wrinkles, which are lines that form from repeated facial movements like smiling, frowning, or squinting. These wrinkles typically appear on the upper face, including crow’s feet, forehead lines, and frown lines...
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